The best way for you to get vitamin D3 into your body is to route it in through your body’s skin. The body makes vitamin D3 in its skin and safely handles the vitamin D3 it makes. It makes vitamin D3 through exposure to sunlight with 295-300nm ultraviolet-B light in it. Vitamin D3 is hydrophobic (“water fearing”). Blood has a saltwater base (what vitamin D3 fears), so the vitamin D3 doesn’t move until it is picked up and carried through circulation by vitamin D-binding protein (made in the liver). In contrast, ingesting vitamin D3 puts it through the body’s digestive system, which results in huge losses (estimated 50-80 percent losses). And it passes through the digestive system unchecked, which can result in dangerous surges of vitamin D3 in circulation, a condition that creates hypercalcemia (which is why the FDA recommends a limit of 5,000 IU a day for oral consumption of vitamin D3).
Whether vitamin D3 is produced naturally in skin or is added to skin (what we do here at workoutD.com), once attached to vitamin D-binding protein vitamin D3 is freed to move out of skin and through the body, under the body’s full control. On passing through the liver vitamin D3 is converted to calcidiol:
The conversion of vitamin D3 to calcidiol is mandatory: it occurs in the liver when vitamin D3 molecules encounter the liver enzyme CYP2R1 in endoplasmic reticulum in the liver (also called “the principal vitamin D 25-hydroxylase”), or when vitamin D3 molecules encounter the liver enzyme CYP27A1 in mitochondria in the liver (also called “another vitamin D 25-hydroxylase”).
The next and final conversion of vitamin D3 is the conversion of vitamin D3 to its biologically active form, which takes place in the body mostly in the kidneys, to calcitriol (1,25(OH)2D3):
Very little 1,25(OH)2D3 is ever seen in circulation, because it is produced only on demand and is put to work immediately by vitamin D receptors which are located throughout the body, so has little opportunity to circulate. And as soon as active vitamin D3 begins increasing circulating calcium ions (Ca2+), the body begins producing calcitonin to keep the amount of circulating calcium in check (to prevent hypercalcemia (overdosing)).
Active vitamin D3 (also called calcitriol or 1,25(OH)2D3 (1,25-dihydroxycholecalciferol))
– 1,25(OH)2D3regulates calcium and phosphorus homeostasis (the calcium and phosphorus balance in circulation) and is essential for maintenance of bone mineralization. As part of this role, vitamin D3 increases calcium and phosphorus uptake in the intestine. Calcium and phosphorus homeostasis, calcium and phosphorus uptake, and bone mineralization have been known roles of vitamin D3 in the body for more than one hundred years now.
– 1,25(OH)2D3 About two decades ago, 1,25(OH)2D3 also came to be described as a “transcription controller,” turning the transcription of genes on and off. Now, as research in the genetics frontier of modern medicine advances, 1,25(OH)2D3 is described as a “transcription factor” that promotes/discourages and speeds/slows the transcription of hundreds of genes, working alone, or working with other transcription factors to direct cell division, cell migration, cell organization, cell growth, and cell death throughout the life of the cell, transcription, first to messenger RNA, and then to protein.
– 1,25(OH)2D3 reduces the occurrences of colorectal, breast, and prostate cancers, autoimmune diseases (including type 1 diabetes mellitus, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus), type 2 diabetes mellitus, seems to limit cognitive deterioration and disease progression in subjects with neurodegenerative diseases, seems to protect the unborn in pregnant women from several adverse effects, reduces the incidence and severity of the coronavirus disease (COVID-19), offers promising improvements in the management of atopic dermatitis (eczema) and Crohn’s disease, and influences the immune system, through the vitamin D receptors (VDRs) that are expressed in several types of white blood cells, including monocytes and activated T and B cells.
–1,25(OH)2D3 creates calcium-binding proteins and phosphatases to break up accumulated calcium phosphate salts, and return the useful calcium and phosphate ions they are made of back to circulation.
The body is nerve, muscle, bone, all the support systems they need, and open (extracellular) space (also called ground). The body is organized for thinking (nerve) and acting (muscle and bone). Vitamin D3 uses phosphatases and calcium-binding proteins it creates to clean ground. Calcium phosphates form spontaneously from circulating calcium and phosphate ions. (1) calcium phosphates accumulate everywhere throughout the body on ground, (2) calcium phosphate accumulation is increased during fever, (3) is increased during times of metabolic imbalances, (4) is increased during pregnancy, and (5) is increased at and around sites of injury. Calcium phosphate accumulations “dirty up” ground and/or clog open spaces. As a result, the body, can’t get nutrients, especially oxygen, to cells efficiently. Clear, direct, and straight forward thinking and acting is impeded. Vague aches and pains without clear origin develop and distract away from clear thinking/acting. Cleaning ground of the calcium phosphates results in healthy bodies that better think/act.
Where there are large accumulations of calcium phosphates on ground, circulating macrophages combine and make themselves into multinucleated macrophages (Figure 4), to surround (using neoplastic, “new form” membrane), break up, dissolve, encapsulate, and transport away calcium phosphate masses, another tool the body uses to thoroughly clean ground.
Figure 4: A multinucleated macrophage looking for some calcium phosphate to consume.
WorkoutD is a method of rubbing vitamin D3 (in paste form) into your skin. Once a day rub in up to 200,000 IU of vitamin D3 (200,000 IU should be more vitamin D3 than you can use, no matter how active you are). It will be brought into circulation all day as vitamin D-binding protein is made available to pick the vitamin D3 up and circulate it. Target shoulders, elbows, wrists, hips, knees, and ankles.
WorkoutD with exercise extends open space calcium phosphate cleanup to every corner of the body. You will be working locally cleaning the extracellular (ground) spaces around cells and working system-wide using circulating multinucleated macrophages to locate and remove calcium phosphate masses throughout your body. Exercise for circulation.
J. Dalen, at WorkoutD